Colonialism has been a historical phenomenon that stretches around the globe and across time. In a modern sense, colonialism, in fact, began with the ‘Age of Discovery’. Colonialism impacted the lives of the natives in a mostly negative way. It started spreading its tentacles in the Indian subcontinent with the establishment of the East India Company by the Britishers in 1600AD. Africa became the target of the third wave of European colonialism after that of America and Asia. The natives of both countries were oppressed, exploited, and subjugated by the British. They were forced to adopt alien religion and culture and had to abide by their law. The worse effect of colonialism was to be seen in the mindset of the natives who were badly affected. Amitav Ghosh’s ‘Sea of Poppies’ and Chinua Achebe’s ‘Things Fall Apart’ are an account of the colonial impact of British rule in India and Africa respectively. By virtue of being human beings, Indians and Africans share a common saga of the consequences of exploitation. The present paper, with the help of these two novels, attempts to analyze and compare the socio-cultural and religious impacts of such transgression in the lives of these two big races on the earth, and study the differences prevailing therein, if any.