Any pharmacotherapeutic approach's main goal is to effectively administer the right medicine at the right concentration at the right place through the use of a rationally designed delivery mechanism. Even though their therapeutic validity is questioned because to their limitations, such as limited lipid solubility, poor stability, big size moiety, and unnecessary gastrointestinal metabolism, phytopharmaceuticals have been used to treat illnesses for millions and billions of years. Using phyto-phospholipid complexes, which combine active ingredients with label-friendly phospholipids, are a potential way to improve the oral bioavailability of components. Phospholipid complexes are a crucial component and are made possible by hydrogen bond interactions between active components and phospholipids. Phyto denotes a plant, and some implies like a cell. A cutting-edge technology called a phytosome is used to make phytopharmaceuticals, which are made of herbal extracts that are surrounded and bound by lipid. The majority of phytomedicine's bioactive components are water soluble substances like flavonoids. Due to their water solubility and lipophilic outer layer, phytosomes exhibit better absorption than conventional herbal extracts. These results in better bioavailability, a decrease in clearance rate, higher dissolution, and an amplified solubility of a variety of natural products by several folds. Due to increased pharmacological and pharmacokinetic properties, phytosomes can be utilised therapeutically as dietary supplements and to treat both acute and chronic liver failure. There are numerous products on the market that use the phytosome technology, including herbal extracts and phytochemicals like curcumin, ginkgo biloba, grape seed, silymarin, and many others that have significant medicinal promise. The current review highlights the preparation process, properties, benefits, characterization, applications, and key findings of recent research on phytosomes from our own perspectives, which can provide new directions and advancements for herbal dosage forms as well as the technical aspects of phyto-phospholipid formulations to meet future challenges.