Analytical procedures play an important part in delivering solutions such as development. The rapid growth of pharmaceutical industries and medication production in many parts of the world has increased the demand for innovative analytical techniques in the pharmaceutical industries. As a result, developing analytical methodologies has become a vital aspect of research. This review paper provides a description of HPLC Method Development and Validation Procedures for Anti-Diabetic Drugs, with a particular emphasis on Metformin, Saxagliptin, and Dapagliflozin. Drug analysis is critical to the advancement of medicine, its manufacture, and its therapeutic application. A variety of appropriate techniques, including as uv spectrophotometers and HPLC, are used for the simultaneous estimate of medicine included in dosage forms. These are tough, forceful tactics that are also extremely particular, accurate, correct, linear, and fast. Quantitative chemical analysis is used in the pharmaceutical sector to ensure that the raw materials utilised and the final product obtained fulfil the specified specifications.