This research investigates the role of Cyber-Physical Systems (CPS) in enhancing supply chain resilience, particularly in the face of disruptions and uncertainties. The study presents a comprehensive examination of CPS adoption within supply chains, emphasizing its multifaceted contributions to resilience, efficiency, and adaptability. Key findings underscore the benefits of real-time data monitoring, predictive maintenance, and digital twins in optimizing supply chain operations. Furthermore, the research highlights the significance of CPS in promoting visibility, transparency, and customer-centric approaches. It discusses the economic advantages, rapid response capabilities, early disruption detection mechanisms, and sustainability implications associated with CPS integration. As dynamic capabilities that empower supply chains to absorb, adapt, and recover, CPS technologies are pivotal in navigating disruptions and aligning with evolving customer expectations. However, the study acknowledges challenges such as data security, scalability, and the importance of cross-functional collaboration. In conclusion, this research advocates for the holistic adoption of CPS technologies and emphasizes the need for ongoing exploration to ensure supply chain resilience and competitiveness in an ever-evolving global landscape.