Ages ago, treatment of several ailments as neurodegenerative diseases was established using natural resources, from both animal and plant origins. Till now susceptibility of cognition to wain either by natural/ pathological aging or oxidative stress is a major concern and is continually increasing. One of these major health concerning neurodegenerative diseases in addition to its treatment, is MS, and has been a challenge for many years. Some dietary components that contain polyphenols as dark chocolate (DC) have shown that if obtained in proper amounts could enhance the cognition process. Thus, we aimed to assess a more natural treatment/prophylaxis with reduced side effects, using DC as a main nutrition component in ethidium bromide-treated mice. Treatment was assessed through the measurement of neuroinflammatory and remyelination parameters to establish the efficacy of the formulation in both treated and untreated mice. Mice that received DC in their diet (both control and MS-induced) showed lower levels of TNF, IL17 &6, glycophore, and higher levels of protein thiols and Nrf2, and brain proteolipid protein when compared to their respective controls, they also showed better cognition in Morrice Maze behavioral test, and improved Histopathological findings. Hence, from the aforementioned revelations, DC represents a safe promising natural neuro-enhancing agent that can be used to improve the prognosis of MS.