Since the beginning of the coronavirus disease of 2019 (COVID-19) pandemic, it was such a tough time for everyone including the physical, social, financial, and mental aspects. The situation is difficult mainly for people in rural areas with a low income. The current study aimed to identify the prevalence and severity of depression and the socioeconomic status of Ghor al-Safi residents and compare those infected by severe acute respiratory syndrome coronavirus 2 (SARS-cov2) and non-infected participants during the COVID-19 lockdown. Material and Methods: A cross-sectional study was conducted in Ghor al-Safi (Al-Karak, Jordan) using a google form questionnaire. The current study included 285 participants who were classified into two groups: Group of participants previously infected by SARS-cov2 (135 participants) and another group of participants never infected (150 participants). The followings were assessed for both groups: Demographic data, socio-economic and depression. Results: The mean age of the overall studied participants was 35.5 (±12.8) years. About 21.1% of participants had comorbidities. The depressive symptoms were assessed using Patient Health Questionnaire-9. About 57.2% of all participants had some degree of depression. The infected group had a significantly higher mean depression score than the non-infected group (p=0.02). Nearly,31.9% of the participants lost their jobs. The presence of co morbidity, getting infected with SARS-cov2 once and twice were significant predictors of the impact of COVID-2019 pandemic on financial status. Conclusion: About half of Ghor al-Safi participants were infected by SARS-cov2. This was associated with some degree of depression and financial difficulties.