The aim of present research is to design and develop topical nanoemulgel of curcumin as effective treatment for eczema. Various oil-in-water nanoemulsions are prepared by the spontaneous emulsification method. Further, curcumin (a natural bioactive) was selected as a therapeutic agent to incorporate in to the hydrogel system to design & develop nanogel pharmaceutical products for Eczema. Curcumin possesses remarkable anti-inflammatory, anti-oxidant and anti-infective activity. Topical nanoemulsion containing 1% curcumin with different oils (oleic acid), surfactant (tween 80), co-surfactant (PEG 400) and distilled water. The nanoemulsion formulations that passed thermodynamic stability tests were characterized for appearance, pH, FTIR, Viscosity, Drug content, % Drug entrapment efficiency & In-Vitro drug diffusion study of curcumin determined by Franz diffusion cell and stability study. Nanoemulsion gel were developed by incorporation of optimized nanoemulsion in to HPMC k15 and Carbopol 934 and characterized by physical evaluation and Rheological studies.