The purpose of this effort is to design, produce, and test extended-release trilayer matrix tablets that contain Ramipril for the purpose of administering the medicine over a longer period of time. Direct compression method with Response surface technique for polymers that included HPMC K4M, HPMC K15M, and xanthan gum (low, intermediate, and high concentrations) were used to construct a total of twelve different formulations (RTF1–RTF12) for the active layer (middle layer) by utilising Design of experiment software. These formulations were named RTF1–RTF12. One formulation was selected on the basis of its physicochemical qualities and drug release, and it was further made into prolonged release trilayered matrix tablets by altering amounts of polymers using the direct compression method. These tablets were then put through an evaluation.