The transdermal drug delivery system of Empagliflozin has been formulated by using the solvent evaporation method using polymers such as Ethyl cellulose PVP, and HPMC K15M in different proportions. PEG-400 is used as a plasticizer and propylene glycol is used as a penetration enhancer. The IR studies confirmed the compatibility between the drug and the polymers. All the patches were uniform concerning physiochemical evaluation. The effect of polymer concentration on physiochemical parameters of prepared formulations like thickness, weight variation, folding endurance, moisture content, moisture uptake, tensile strength, drug content, and in-vitro release was evaluated. The purpose of this research was to develop a matrix type of transdermal therapeutic system containing Empagliflozin with different ratios of hydrophilic and hydrophobic polymeric concentration by the solvent evaporation method. The prepared patch showed satisfactory physiochemical characteristics of weight uniformity, thickness, folding endurance, moisture uptake, tensile strength, and moisture absorption for the stability of the formulation, and drug content was uniform in all patches. In vitro study done by Franz diffusion cell having semi-permeable membrane to determine the amount of drug present in the formulated patch. In formulation based on the present study formulation , F5 shows 92.29% drug was released within 6 hrs. Conclusion: the study concludes that transdermal patches can extend the release of Empagliflozin for many hours with the help of polymer ethyl cellulose and PVP further it also helps in avoiding first-pass metabolism.