Antihypertensive medication perindopril is used to treat hypertensive urgency. Angiotensin Converting Enzyme (ACE) inhibitors are a class of medications that includes the drug perindopril ter-butyl amine. It tastes bitter. Therefore, the flavor needs to be covered up in order to lessen its harshness, make it more palatable, and boost patient compliance. The preparation of flavorless compounds of perindopril erbumine was the goal of this research project. Traditional taste-masking methods, such as the use of sweeteners, amino acids, and flavoring agents, sometimes fail to cover up the taste of extremely bitter medications. The goal of this study was to develop an inclusion complex creation array employing HP -cyclodextrin to conceal the highly bitter taste of perindopril erbumine. The study convincingly showed that using HP Beta cyclodextrin in a 1:3 kneaded ratio completely masks the harsh taste of perindopril erbumine.