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ISSN 2063-5346
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Design, development and influence of super disintegrants on solid dispersion based taste masking orodispersible tablets of racecadotril

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Kumara Swamy Samanthula1, Lakshmi GNA2, Jithendar Reddy Mandhadi1*, Nurjamal Hoque1, Saikat Sen1, Agaiah Goud Bairi3
» doi: 10.48047/ecb/2023.12.10.880

Abstract

Orodispersible tablets are a kind of solid dosage form that easily disintegrate or dissolve in water or a little amount of salivary fluid to generate a solution or suspension. Dispersible pills are a good option for patients of all ages who have trouble swallowing capsules and tablets, but notably young children and the elderly. Some drugs' bioavailability may be improved due to drug absorption in the oral cavity, as well as pregastric absorption of saliva-containing dispersed medicines that move down into the stomach. The current study used the direct compression method to manufacture orodispersible tablets (ODTs) of racecadotril employing sodium starch glycolate, crospovidone, and sodium croscarmellose as super disintegrants. The developed orodispersible tablets were assessed for several characteristics, including drug-polymer interaction, water absorption ratio, and in-vitro drug release studies. The tablets developed using the direct compression technique had a weight variation of less than 7.5%, a hardness of 3.07±0.35 to 3.94±0.33 kg/cm², a percentage friability of 0.41±0.78% to 0.95±0.33%, in-vitro dispersion times of 19±1.41 to 32±1.33 sec, drug content uniformity of 98.55±1.44 and 99.88±1.55%, wetting times of 32±1.28 to 49±1.55 sec, a water absorption ratio of 65.66±1.12% to 85.72±1.24% and disintegration times of 10±1.24 sec to 22±0.66 sec. Oro-dispersible tablets made with crospovidone (F6), which contain crospovidone at a concentration of 6%, were selected as the best batch due to rapid disintegration at 10 sec and relatively quick drug release of 99.82±1.55% at 8 minutes.

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