The current research objective is to develop and assess transdermal patches containing voriconazole by solvent cast method. Voriconazole is an antifungal drug used that is used to treat a variety of infections of yeast or other fungi. Because they are simple to use and improve patient compliance, transdermal medication delivery systems have begun to acquire popularity and acceptability as novel drug delivery methods. In the current study, polymers such HPMC K 15M, HPMC K 100M, and HPMC K 200M are used to generate Voriconazole transdermal patches. The solvent casting procedure used to make Voriconazole transdermal patches. Tween 80 plasticizer dosage was essential for the separation and patch forming features. The formulations F-5 were determined to be a satisfactory batch and were optimised for the desired qualities. Studies on stability were done on the chosen formulation F5, which was kept at 40°C 2°C / 75% 5% RH for three months. After being stored for 1, 2, and 3 months, samples were tested and assessed.