The present investigation was aimed at designing controlled release matrix tablets of Simvastatin, using natural polymers like guar gum and xanthan gum in combinations of various concentrations, to produce a controlled release of Simvastatin to improve the efficacy and patient compliance and drug release profiles of the optimized formulation. The tablets' medication release adhered to zero-order kinetics. Due to its longer half-life and lower clearance rate compared to developed immediate-release tablets, controlled-release tablets were found to have a better degree of drug absorption, according to in vitro experiments. For a period of 12 hours, matrix formulations based on Xanthum gum displayed controlled release. Simvastatin tablets with controlled release showed better absorption than tablets with developed IR. Our findings imply that Simvastatin controlled-release tablets are an effective medication delivery methods that will overcome the drawbacks of conventional therapy.