Reactive distillation syndicates reaction and separation in one unit to simplify the process operation Reactive distillation column is one of the key elements in the process of Petroleum and chemical industries, which is having nonlinear, multivariable and non-stationary characteristics. The conventional controller like PID provides fruitless control action for nonlinear process. This paper deals the design of the model predictive controller to control composition of the Reactive distillation column.. Here the Recursive Least square technique is used to estimate the parameters and build the exact model of the Process. The MATLAB policy is used and accomplished of the GPC, Fuzzy and Conventional IMC based PID controller.