In this study, we undertook a detailed characterization of three organic compounds: 5- [difluoro(methylsulfanyl)methyl]-1,3,4-oxadiazole-2-amine, (5-amino-1,3,4-oxadiazol2yl)methanetriol, and 5-(trichloromethyl)-1,3,4-oxadiazole-2-amine. The purpose of the study was to affirm their identities through melting point determination and mass spectrometry analysis. Melting point determination confirmed the purity of the compounds while mass spectrometry offered an in-depth view into the compounds' molecular structures through their unique fragmentation patterns. The outcomes validated the proposed structures of these compounds, contributing to our understanding of their properties. This fundamental characterization sets the stage for potential future applications of these compounds, such as their use in medicinal chemistry for antimicrobial, anti-inflammatory, and anticancer activities