Background: In general, the chalcones and benzofuran are exhibiting various biological activities. The evaluation of pharmacological potential of chalcones of benzofuran as antidepressant agents are explored in this research work. To get insight of the intermolecular interactions, the molecular docking studies are performed at active site of MAO-A enzyme. Aim: In this study, an attempt has been made to generate new molecular scaffold which contains chalcones of benzofuran.