A series of ten novel aniline linked quinazoline derivatives (5a-5j) were synthesized in good to excellent yields by multicomponent reaction. Compound 4-(2-chloroethyl)-2-methylquinazoline (3) was generated by coupling reaction of N-phenylacetamide (1) and 3-chloropropanenitrile (2) in presence of trifluoromethanesulfonic anhydride,2-chloropyridine and carbon tetra chloride under reflux. Compound (3) up on condensation with different substituted anilines in the presence of trimethyl amine as a catalyst and DMF yielded the final product. The synthesized derivatives were characterized by 1H NMR, 13C NMR, ESI-MS. Subsequently, the compounds were screened for their cytotoxicity potential against HeLa, LoVo, PA-1 and MCF-7 cancer cell lines and one normal human fibroblast using the MTT method. Designed quinazolines derivatives were studied for their molecular interaction with the target EGFR kinase (2ITY) using the molecular docking tool GLIDE.