Health care providers face a tremendous difficulty in dealing with the widespread, substantial, and disabling condition of chronic neuropathic pain. Although there are several pharmaceutical options, no standard treatment currently exists for neuropathic pain that is effective in the long-term. The science of medication research has shifted its focus away from synthetic chemicals and toward herbal formulations in recent years. As a result, we evaluated all the available data regarding the effectiveness of herbal medicines and plants in relieving neuropathic pain. The beneficial effects of each plant are described, including their use in animal and human models of neuropathic pain. Additionally, the probable mechanisms contributing to the protective effects are investigated. Furthermore, the most well-studied mechanisms in herbal pain therapy include the antioxidant activity, anti-inflammatory, anti-apoptotic, neuroprotective, and calcium inhibitory actions. For the management of neuropathic pain, this article contains a list of TIMPs and isolated compounds that have shown promise in clinical trials. Researchers receive help in their search for a viable therapy for neuropathic pain.