In the present study mucoadhesive buccal tablets of Cilnidipine were developed by using mucoadhesive polymers for the treatment of hypertension. Nine formulations were prepared by using DoE method called Extreme Vertices Mixture Design. Hardness (kg/cm2) and drug release at 12 hr (%) were considered in the design as dependent variables for the development of Cilnidipine buccal tablets and the independent variables factored in the design were HPMC K4M, HPMC K15M and Carbopol 934. Pre compression studies like angle of repose, bulk density, tapped density, Hausner’s ratio and Carr’s index were studied for powder blends and the values shows that the granules having good flow properties and compression characteristics. Post compression studies such as weight variation, thickness, hardness, friability, content uniformity, swelling index, surface pH, bioadhesive strength, in vitro dissolution, and stability studies were carried out. BTF9 formulation was selected as best formulation based on physico chemical parameters and in-vitro dissolution and diffusion values. Stability studies for the best selected formulation showed no significance changes in the parameters such as hardness, drug content, in-vitro dissolution and diffusion studies. Therefore, the buccal tablets of Cilnidipine can be developed successfully by using mucoadhesive polymer for the treatment of hypertension.