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ISSN 2063-5346
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DEVELOPMENT AND CHARACTERIZATION OF FAT-WAX MATRIX TABLETS OF FLURBIPROFEN BY MELT GRANULATION TECHNIQUE USING NATURAL AND SYNTHETIC EXTENDERS

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Dr. Zakir Hussain, Dr. V. Santhi Sree, Syed Shah Abdus Salaam, Shaik Shireen
» doi: 10.48047/ecb/2023.12.si7.145

Abstract

The Fat wax matrix tablets of Flubriprofen were prepared by melt granulation technique using various compositions like oleic acid and carnauba wax, bees wax, Magnesium sterate, Talc, micro crystalline cellulose, with different concentration. Total number of nine formulations was prepared and evaluated. The direct correlation between, dissolution profile for the optimized formulation F3 containing oleic acid and carnauba wax as a disintegrating agent. After evaluation it has been noted that Batch F3 containing oleic acid has shown good results in powder characteristics, post formulation evaluation and hence it was considered as an optimized formulation. Disintegration of batch F5 was less than all other batch. Hardness and Friability of batch F3 were also good. Stability study indicated that there was no change after one month

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