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ISSN 2063-5346
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DEVELOPMENT AND CHARACTERIZATION OF KOJIC ACID LOADED DRUG DELIVERY SYSTEM FOR THE TREATMENT OF SKIN DISORDERS

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Prantika Mondal, Dr. Vijay Bhalla, Reena Tyagi
» doi: 10.48047/ecb/2023.12.Si5.384

Abstract

Background: For the effective hyperpigmentation treatment potent melanin synthesis inhibitors such as kojic acid was used. Objectives: The objective of the study is to develop and characterize kojic acid loaded nanoemulsion, for hyperpigmentation treatment in cosmetic and dermatological products. Methods: Kojic acid loaded nano emulsion was formulated by high-speed homogenization method. It was characterized by transmission electron microscopy (TEM), in addition to the evaluation of the release profile and permeation profile. Results: The FTIR, XRD and DSC results indicated the entrapment of Kojic acid in nanoemulsion without any chemical interaction with other excipients. The optimized formulation yielded the polydispersity index 0.2, particle size 184 nm, and pH 5.62. The TEM analysis of optimum formulation of kojic acid showed that the particles were small spherical shaped. The in vitro drug release studies and ex vivo permeation evaluation of formulation showed that 87.67 % of release at 12 h and 81.24 % of permeation of the drug at 8 h of application respectively. The stability studies were carried out for 90 days at 25°C/60% and 40±2°C /75±5% RH. At 25°C stability studies indicated that Kojic acid nanoemulsion was stable but at 40°C slight yellowish color appears in the formulation. Conclusion: The findings revealed that the proposed Kojic acid nanoemulsion is a promising platform and suitable for topical application in the treatment of skin disorders.

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