This study focuses on the formulation and characterization of mouth dissolving films (MDFs) loaded with zolmitriptan (ZOL). Eleven different formulations of ZOL MDFs were prepared, each containing 1.25% w/w of the drug, and subsequently evaluated for various parameters. The morphological properties assessment revealed that all formulations exhibited homogeneity, transparency, and colorlessness, with both sides being smooth. The thickness of the films varied between 70.00±0.00 and 108.33±4.08 mm. The formulation F2(A) demonstrated the highest drug content at 1.39±0.01%, while F6 exhibited the lowest at 0.70±0.01%. The weight variation ranged from 4.00±0.01 in F7 to 5.67±0.03 in F2(A). The tensile strength exhibited variability from 3.38 ± 0.26 µm to 15.32 ± 0.11 µm in F5, and the % elongation ranged from 32.50 ± 0.52 cm to 97.64 ± 1.40 cm. The folding endurance showed a range from 16±60 in F2(A) to 115±50 in F7. The disintegration time, assessed by both drop and Petri plate methods, varied across formulations. The drop method indicated the lowest disintegration time in F7 and F4 at 11.00±0.00, while the Petri plate method showed the lowest time of 22.33±0.58 seconds in F4. Based on the overall evaluation, formulation F7 was deemed the ideal formulation. In vitro drug release from ZOL, F7 was observed to be 101.94±1.61 in 180 seconds. The first-order release kinetics showed an R2 value of 0.996, while the Higuchi kinetics exhibited an R2 value of 0.993, indicating that the formulation follows first-order release kinetics. Stability studies conducted over six months demonstrated that, at the end of the period, the formulation remained transparent with a weight variation of 97-99% and drug content of 96-99%. Therefore, it can be concluded that the F7 formulation of Zolmitriptan MDF is a viable option for the efficient administration of the drug