Introduction: Saffron is one of the oldest spices, its history going back to the highest antiquity. Biologically known as Crocus sativus belongs to the Iridaceae family. Traditionally Saffron is used in treatment of depression, Sexual dysfunction, Antioxidant, arrythmia and hypertension. Numerous investigations have shown that both arrythmia and hypertension. can be controlled by their entrapment in submicronic colloidal systems (nanoparticles). Objectives: This research article aims to formulate Saffron extract based polymeric nanoparticles by the solvent evaporation method, Various Parameters like particle size, poly dispersity index, and zeta potential were calculated, Compatible studies between the nanoparticles and the loaded drug were analysed using FT-IR, invitro drug release studies were performed. Areas covered: Polymeric nano formulations have gained considerable attention as effective carriers to enhance the bioavailability of drugs. This article covers an overview of saffron as potential source of arrythmia and hypertension, increase in bioavailability through nano formulations. Conclusion: Saffron extract based polymeric nanoparticles by the solvent evaporation method were successfully prepared suggesting a comparatively suitable option for treatment of disease with fewer side effects and increased affinity of drug.Given the aforementioned information, formulated nano particles should be investigated for further in vivo studies.