Mebeverine hydrochloride is known to suffer from extensive first pass effect. In an attempt to improve its oral bioavailability and possibility to restrict its absorption only to the colon, mebeverine microspheres of guargum were prepared by emulsion dehydration method. Four formulations were prepared with varying drug and polymer ratio. These formulations were subjected to various evaluation parameters like percent practical yield, entrapment efficiency, particle size, in vitro drug release. Practical yield of the microspheres GG3 was up to 85.06 ± 0.97% with encapsulation efficiency up to 86.53 ± 2.21%. Scanning electron microscopy confirmed that the microsphere structures were smooth, spherical, and discrete and the particles were of the size range 74.7 ± 3.46-149.7 ± 3.4 μm. On the basis of drug content, particle size and in vitro release studies, formulation GG3 was found to be optimal. Optimized formulation was subjected to double coat to control the drug release in stomach and to achieve controlled drug release in the colon. Formulation GG17 coated with chitosan and carrageenan was found to elicit the desired results in a controlled manner