This scheme of research was to develop a nanogel loaded with herbal-Bioactive Antidiabetic Cucurbitacin (CBT) from optimised nanoemulsion. Optimisation of nanoemulsion was based on selection of CBT-NE4C on basis of stability, characterisation, profile of in-vitro release kinetics and ex-vivo S.P.S. (skin permeation study). The optimised nanoemulsion was scanned for their Z-average, TEM, ζ-potential, RI, and rheological characteristics. Finally, nanogel (CBT-NG) was developed form nanoemulsion to increase its adherence and application compliance with live-skin. The in-vivo Antidiabetic activity was performed through transdermal route in streptozotocin-induced diabetic rats along with placebo. The data analysis reveals that the CBT in nanogel has better Antidiabetic activity with lower dose as compared to neat formulation. This positive result is attributed towards increased solubility of the drug and enhanced permeability from nanogel.