.

ISSN 2063-5346
For urgent queries please contact : +918130348310

DEVELOPMENT AND EVALUATION OF SELF EMULSIFYING DRUG DOSAGE FORMULATION (SEDDF) OF COMMIPHORA WIGHTTI EXTRACT

Main Article Content

Mahendra Kumar Singh, Mahendra Pratap Singh, Pratyush Jain, Gaurav Tiwari
» doi: 10.48047/ecb/2023.12.si4.1591

Abstract

The herb Commiphoramukul, sometimes known as guggul, is commonly utilised by rural and tribal people to treat a variety of illnesses. The idea that natural medicines are safer and have fewer negative effects than synthetic ones makes them more acceptable. The demand for herbal formulations is rising on the global market. In the current work, an effort was made to improve the solubility, dissolution, and bioavailability of commiphorawightti extract (guggul) by developing and evaluating a self-emulsifying drug dosage formulation (SEDDF). Guggul extract's solubility in various oils, surfactants, and co-surfactants was measured. For the purpose of improving the formulation of microemulsions, pseudoternary phase diagrams were adopted. Based on their in-vitro drug release profile, globule size, zeta potential, and self-emulsifying assessment, the produced formulations of SEDDF were assessed. Studies on the in vitro release of the improved formulation F3 showed that the Higuchi equation best described the release profiles of SEDDF of guggul extract because the plots had the highest levels of linearity (coefficient of determination, R2=0.994). The optimised SEDDF formulation F3 was seen to have a 98.15% release after 60 minutes.

Article Details