One of the most prevalent malignant tumours is hepatocellular carcinoma (HCC), and the majority of HCC patients receive an advanced-stage diagnosis. [1-2] Sorafenib Tosylate is frequently used for liver cancer treatment. In addition to increasing sorafenib's water solubility, sorafenib Tosylate loaded polymeric mixed micelles of soluplus and Vitamin E TPGS 1000 additionally enhance sorafenib's bioavailability. Thin-film hydration method was used for producing the mixed micelles, which helped to increase the stability and effectiveness of drug solubilization. To determine the ideal polymeric ratio, we generated several batches of sorafenib micelles using different ratios. Polymers like Soluplus, TPGS 1000, and Pluronic F127 were evaluated during the dosage form development. The entire formulation batches the F2 batch with optimal drug content having 87.1 nm particle size and 1 mV zeta potential. By using FTIR, SEM, TEM, DSC, and microscopic analysis, the formulation was assessed