The therapeutic potential of Holoptelea integrifolia Planch., a medicinal plant widely used in traditional medicine, has gained significant attention due to its diverse pharmacological activities. However, the effective delivery of its bioactive compounds remains a challenge due to their poor solubility, low bioavailability, and instability. In this study, we aimed to develop and evaluate a gel formulation loaded with Holoptelea integrifolia Planch. extract-loaded solid lipid nanoparticles (SLNs). The gel formulation was evaluated for rheological properties, stability, and in vitro release kinetics. The results exhibited that the developed gel formulation exhibited desirable rheological characteristics, providing ease of application and prolonged contact time with the skin. The gel formulation demonstrated sustained release of the bioactive compounds, ensuring controlled and targeted delivery. The findings of this study highlight the potential of the gel formulation as a promising topical delivery system for Holoptelea integrifolia Planch. extract, offering enhanced therapeutic efficacy for various dermatological conditions.