This research work was carried out to measure the gastro retentive efficacy leading towards the antiulcer potential of curcumin loaded floating micro sponges for improved site specific absorption for gastric ulcer in clinical platform. The microsponge were prepared by the modified quasi emulsion solvent diffusion method entrapping pure curcumin. The process and formulation parameters were well optimized leading to the ideal % entrapment efficiency, % buoyancy and % cumulative drug release. The in vitro release and the release studies were carried out at different pH for investigation of gastroretentive properties resulting in best fitted zero order models. The developed curcumin loaded floating microsponge formulation were well characterized for TEM, Zeta sizer, zeta potential showing well architecture of microsponge with ideal size micrometre size range (175 µm) along with (% entrapment efficiency (76), % buoyancy (82) and % cumulative drug release (90). DSC investigations confirmed molecular dispersion of the drug in the microsponge’ polymeric matrix. Overall the current approach validated the stable and dispersed formulation showing ideal floating and gastroretentive ability of microsponge for treatment of gastric ulcer in clinical platform.