Ocimum sanctum has a rich and spurious background renowned for its tremendous curative and multifunctional functionality since the Vedic age. Ocimum tenuiflorum is considered as ubiquitous aromatic plant belonging to family lamiaceae. It is known as Holy Basil in English and Tulasi in Sanskrit. Tulsi plant is the rich source of vital nutrient such as vitamin A, vitamin C, calcium and phosphorus. It contains several chemical constituents such as, oleanolic acid, rosmarinic acid, ursolic acid eugenol, linalool, carvacrol, β elemene, β caryophyllene, germacrene. Ocimum sanctum has various medicinal property like diuretic, anti-oxidant, blood purifier, larvicida, expectorant. Recent scientific work provides excellent proof that tulsi increases stamina, alleviates inflammation, decreases cholesterol, removes contaminants, avoids radiation, prevents stomach ulcers, decreases fevers, promotes digestion and provides a rich natural antioxidants and other nutrients. This study was conducted to develop and evaluate Emulgel formulations containing Ocimum Sanctum plant (leaves, seeds, flower) extract. The formulations were prepared using different polymers (Carbopol 934, Carbopol 940, and HPMC) and a consistent composition of other excipients. The extractive values of the Ocimum Sanctum Seed Extract in different solvents were quantified, and phytochemical analysis revealed the presence of several bioactive compounds. The Emulgel formulations were evaluated for pH, viscosity, spreadability, extrudability, and in vitro drug release. All formulations showed good skin compatibility, spreadability, and extrudability, with sustained drug release over an 8-hour period. The study concludes that the developed Emulgel formulations containing Ocimum Sanctum plant extract displayed promising properties and performance, indicating potential therapeutic benefits and applicability in controlled drug delivery systems.