The aim of present research work was development and pharmacological assessment of herbal formulation for skin care like acne acne disease. Acne is the most common skin problem which can occur due to a bacterial infection MATERIALS AND METHOD The herbal gel was prepared by using Cascabela thevetia extract, Carbopol-940, Tamarind gum, HPMC, Poloxamer 407, Lecithin, Isopropyl myristate, Triethanolamine, Methyl paraben and distilled water. The prepared herbal gel was evaluated by using a number of parameters. The anti-inflammatory and antiacne activity was assessed with paw edema and invitro antimicrobial activity. RESULTS AND DISCUSSION Optimized formulation F7 of CTEE containing combination 1% carbopol 934 and 1% HPMC K4M was found to be excellent for skin application for the treatment of anti-inflammatory. Poly phenolic compounds CTEE presents in ethanol extract of Cascabela thevetia leaves. It is key components for producing anti-inflammatory activity. It may act as antioxidant and potential inhibitors of cyclo-oxygenase, lipoxygenase and nitric oxide synthase. This gel can be effective for various skin diseases such as abscesses, boil, burns and eczema. Consequently, CTEE bioactive compounds containing is appropriate for topical application. It can offer multiple benefits for skin diseases along with treating inflammation CONCLUSION The prepared gel formulation can be used for the treatment and management of acne diseases