spondylolisthesis refers to the slippage of one vertebral body over the adjacent one. It is a chronic condition that requires early detection to prevent unpleasant surgery. The paper presents an optimized deep learning model for detecting spondylolisthesis in X-ray radiographs. The present review focuses on key advances in machine and deep learning, allowing for multi-perspective pattern recognition across the entire information set of patients in spine disease problems. The techniques discussed could become important in establishing a new approach to decision-making in spine problems based on three fundamental pillars: (1) patient-specific, (2) artificial intelligence-driven, (3) integrating multimodal data. The findings reveal promising research that already took place to develop multi-input mixed-data hybrid decision-supporting models. Their implementation in spine surgery may hence be only a matter of time.