To determine the concentration of azilsartan medoxomil (AM), a chromatographic technique, namely high-performance liquid chromatography with a polar mobile phase approach that is both straightforward and speedy, was designed and validated. The photodiode array detector was the instrument that was utilized for the detection. Chromatographic separation of the analyte AM was achieved in 5.047 minutes. The vital parameters of the Validation of the analytical method were carried out extensively. The detection and quantitation limits were 33.92 µg/ml and 102.78 µg/ml, respectively. Interday and intraday methods evaluated the precision parameter. The calibration curve was found to be linear. The 230 nm wavelength is used to perform detection. The newly developed RP-HPLC method passed Validation with flying colors and can now be used for assay and dissolution testing (AM1-AM11).