The rapid development of technology and the increasingly dynamic changes in the world of work require individuals to have skills that are not only focused on academic abilities, but also non- academic skills such as the 4Cs (Communication, Collaboration, Creativity, and Critical Thinking). Children in orphanages have a greater risk of experiencing developmental delays due to the lack of attention and stimulation from their family environment. The Muhammadiyah Orphanage is one of the institutions that provides protection and guidance to children in need, therefore efforts need to be made to improve the quality of guidance provided through the development of a 4C skills implementation model. This R&D study was conducted at the Muhammadiyah Orphanage in Medan, North Sumatra Province. The study population was all foster children in the orphanage, while the total sample size was 227 foster children. The pre-model test sample used in the study was 1 orphanage with 48 foster children as respondents. The limited trial phase I had a sample size of 56 respondents from 2 orphanages. The limited trial phase II had a sample size of 101 respondents from 4 orphanages. The limited trial phase III had a sample size of 227 respondents from 6 orphanages. Data was collected through inventories, observation sheets, interviews, and documentation. The research results showed that: (1) the IK-4C model is suitable for use in the management of education at the Muhammadiyah Orphanage in Medan to improve the 4C skills of foster children; (2) the output of the IK-4C model, which is the improvement of 4C skills in the model group, is significantly higher compared to the conventional group before the model was implemented; (3) the response from the program managers, orphanage management, and respondents to the implementation of the IK-4C model is quite satisfactory, both regarding the concept of the IK-4C model, its application in technical implementation, and their perception of the IK-4C model; and (4) the determining factors that influence the improvement of 4C skills in foster children are the improvement of communication skills, collaboration skills, critical thinking and problem-solving skills, as well as creativity and innovation skills that are included in 4C skills. The IK-4C model can be developed as an alternative implementation in education management. Development of 4-C Skills Implementation Model for Children in Muhammadiyah Orphanage in Medan City" is that the implementation of the IK-4C model has a significant effect on improving the 4-C skills (critical thinking and problem-solving, communication, collaboration, creativity, and innovation) of children in Muhammadiyah orphanage in Medan City. The results of the study show that the implementation of the IK-4C model has a positive impact on the children's skills, as evidenced by the significant increase in their scores in various aspects of the 4-C skills..