Relevance. Acute destructive pancreatitis remains one of the far from solved problems of modern urgent surgery. High mortality after pancreatic necrosis, especially when a generalized form of the inflammatory process develops, taking into account the very high mortality rate, is considered today one of the most tragic situations in the outcome of the disease. That is why any experimental research in the field of studying the pathogenesis of pancreatic necrosis complicated by sepsis is considered relevant today. Material. In order to model the optimal variant of the course of pancreatic necrosis complicated by sepsis, we have studied 5 series of experiments on animals. Results. As our research and review of the issues discussed on this issue have shown, modeling acute pancreatic necrosis, which could be complicated by sepsis, remains far from being a solved problem of modern experimental surgery. When modeling acute pancreatic necrosis complicated by sepsis, along with the use of all pathogenetically significant factors, a separate link is required, which can radically affect the course of the overall reactivity of the body. Modeling of acute pancreatic necrosis complicated by sepsis is possible only under the condition of a combined approach of both local and general effects.