High-velocity oxy-fuel (HVOF) spray coating plays a major role in many surface treatment methods, which tend to improve erosion and corrosion resistance properties. HVOF is well known for its dense and high-quality coating ability. This is due to the less in-flight exposure time, which tends to have less oxide content because of its high-velocity properties. Among the number of process parameters, porosity and hardness are predominant factors while considering wear rate and corrosion behaviour analysis. The current study aims to optimise HVOF process parameters to obtain maximum adhesion strength values in the WC-10Ni-5Cr coating sprayed on 35 Mo Cr steel. The flow rates of oxygen, LPG, coating powder feed rate, and spray distance are selected in this study as these have a superior influence on the final condition of the coating. Statistical tools like the design of experiments (DoE), analysis of variants, and response surface methodology (RSM) were used to achieve the desired results. As per the result analysis, the oxygen flow rate has a higher effect on the adhesion value of the coating.