The field of drug delivery systems has witnessed significant advancements in recent years, particularly in the development of novel approaches for targeted therapy. This review article provides a comprehensive overview of the latest innovations in drug delivery systems designed to enhance the efficacy and safety of targeted therapies. Various strategies, including nanotechnology, biomaterials, and personalized medicine, are discussed in detail. The importance of targeted drug delivery in minimizing off-target effects and improving patient outcomes is emphasized. Furthermore, the challenges and future directions in the development of novel drug delivery systems for targeted therapy are explored. Overall, this review aims to provide insights into the cutting-edge research in the field of drug delivery systems and its potential impact on the future of targeted therapy.