Background: Neem is a medicinal plant that consists of all aerial parts of the plant known as Azadirachta indica, family Meliaceae. It contains a lot of chemical constituents like the leaf part consisting of a chemical constituent like quercetin and the oil of Azadirachta indica contains Nimbin and nimbidine. The bark contains tannins, gallic acid, and diterpenoids active against klebsiella and staphylococcus species. In this article research is done on the neem plant and gel is prepared from the leaf extract of Neem (Azadirachta indica).