This study examines the digital transformation in the healthcare sector, focusing on the Hospital of Najran. It explores how the integration of digital technologies—such as electronic health records (EHRs), telemedicine, artificial intelligence (AI) diagnostics, and mobile health applications—has revolutionized patient care, data management, and operational efficiencies. The paper analyzes the impact of these digital initiatives on patient outcomes, healthcare delivery, and the overall healthcare ecosystem in Najran. It discusses the challenges encountered during this digital shift, including cybersecurity threats, the digital divide, and resistance to change among staff. Furthermore, the study highlights the strategies employed by the Hospital of Najran to mitigate these challenges, promote digital literacy, and ensure a smooth transition to a more digital-centric healthcare model. The findings underscore the importance of digital transformation in enhancing healthcare accessibility, reducing costs, and improving the quality of care, setting a precedent for healthcare institutions in similar regions.