Hypoglycaemia associated with probable anorexia and alteration of cerebro-cellular mass causes significant reduction in the body weight and cerebro somatic index in the sub-acute chromium [Cr(VI)] exposure at a dose of 10 mg/Kg body weight/day for a period of thirty days.Cr(VI) exerted significant impact on protein metabolism as evidenced by depletion of brain protein contents and increased level of free amino acid nitrogen. Proteolytic enzyme activities like trypsin, cathepsin and pronase were also significantly altered depending on the availability of their substrates. Additionally, the transaminase enzyme activities like GOT and GPT were also elevated in cerebral tissue after chromium exposure. Cr(VI) stimulates stress response in the intracellular settings and drags the cellular saturation into very vulnerable by competing growth efficient biomolecules and other sub-cellular components responsible for crucial physiological performance., like hormonal activity, metabolic integrity and summative physiological homeostasis in the organisms.