A selective, simple, and precise RP-HPLC dissolution methodfor estimating the concentration of Nebivolol and Valsartan in combination dosage form. This experimentalanalysis was performed on a reverse phase high performance high-performance liquid chromatography, (RP-HPLC)C18column(250mmx4.6mm,5μm)byusingMobilephaseAcetonitrile and Potassium dihydrogen Phosphate with buffer pH-3.0 in the ratio of (50:50) at a flow rate of 1.0ml/min and the detected at wavelength 282 nm. In line with ICHguidelines, thelinearity of the analytical method was discovered to be in the range of 25-75 μg/mlrange for Nebivolol. The linearity of the method for Valsartan was 400-1200μg/ml. Nebivolol and Valsartan had correlation coefficients greater than 0.990.The relative standard deviation value for system precision and method was less than 2.0%. All statistical data proves validity of the method andcan be usedforroutineanalysis ofpharmaceuticaldosageform