kidney diseases constitute a common and challenging broad spectrum of disorders that needs more attention to be paid not only by the specialty of nephrology, but also by various medical specialties. Because early recognition and prevention is essential, researchers have been investigating the role of different biomarkers in prediction of kidney injuries to provide early management, and hence better prognosis. Research in this area is of great interest and with a very active research community. Yet, no conclusive opinion about the accuracy of predicting kidney diseases by any of these studied biomarkers was found. There is a rising evidence votes for use of urinary Dickkopf-3 in prediction of AKI, and also as a marker of chronic kidney disease. Recently, Dickkopf-3 gained much attention in the pathophysiology of many disorders of kidney injury. Thus, in this review, we assess the role of DKK3 in prediction of different acute and chronic kidney injury.