Obesity adversely alters the functioning of HPO axis resulting in irregular ovulation or anovulation resulting in infertility. This prospective study was conducted on female patients with BMI>25 (i.e.) overweight patients suffering from anovulatory infertility. The patients were put on low glycemic diet and regular physical exercise for one year with aim of losing weight . They were followed up closely. The study group participants lost on an average 8.5 kg of body weight. The participants who could not adhere to the life style modification plan to reduce weight were treated as controls to evaluate the benefit of weight loss on ovulation. It was a matter of immense pleasure that by the time study was over, 18 patients had delivered healthy babies and 123 patients were pregnant. Weight loss not only improved ovulation but also improved their physical fitness, dietary habits and psychological uplift. Based on the study results, we recommend weight loss therapy to obese patients with PCO for restoring regular ovulatory cycles and achieve conception.