A simple HPLC method was developed and used to study of compatibility between Tezosentan and excipients. Proper formulation is an important aspect of any dosage form design. As a part of preformulation studies was used to investigate the physiochemical compatibility between Tezosentan and various excipients commonly used in tablet manufacturing such as povidone and pvp k-30. Differential scanning calorimetry studies indicated incompatibility with povidone and pvp k 30.HPLC method shows linearity range of 1-10 µg/ml, R2 0.9997 and %RSD was found to be less than 2.The drug exipients results shows that suitability of Tezosentan with selected excipients when stored in elevated temperature condition.