In the majority of developed nations worldwide, cardiovascular illnesses are the primary cause of morbidity and mortality. Toxins, illegal drugs, and pharmaceuticals can all considerably increase the stress on the cardiovascular system overall and should be taken seriously. An overview of medications that may cause specific cardiovascular toxicity is provided in this article. One major worry associated with the use of drugs, both legal and illegal, is cardiovascular damage. It may appear even after an overdose or even after only one injection. When it comes to novel drugs, the majority of what is currently known about these detrimental effects on the cardiovascular system is derived from extensive clinical studies or clinical experience. Because even slight variations in arterial blood pressure and heart rate have the potential to be later connected to increased cardiovascular mortality, all drugs that have such cardiovascular effects must be identified for their potential cardiac harm to the patient.