The cause of dry eye syndrome is a persistent deficiency in lubrication and moisture on the surface of the eye. Burning, itchy, tired, and red eyes, as well as gritty and dry eye sensations and a feeling of a foreign body, are all signs of dry eye syndrome. According to studies, post-menopausal women are more likely than men their age to experience dry eyes. The aim and objectives of the study were to find out how common dry eye syndrome is among post-menopausal women at a tertiary care hospital and to analyze the sociodemographic characteristics that may be associated with the condition. Methodology: The cross-sectional study was carried out at the tertiary care hospital in Udaipur. 100 Post- menopausal women were enrolled for the study. The Schirmer's test was employed to see dry eyes are present or not. Results: In the study's participants, the average age at which menopause began was 45.6 ± 31.8 years. A 39.5% prevalence of dry eye condition was discovered. The most prevalent type of ocular dryness among research participants was mild (20.5%). Age was significantly correlated with a higher prevalence of dry eyes. Conclusions: Although not a life-threatening condition, dry eye syndrome impairs quality of life and causes ocular discomfort. Neglect may even result in blindness.