Nanotechnology refers to the modification and synthesis of extremely small nanosized particles or devices and depend on the characteristics and interaction of atoms. These devices help in diagnosing and treating various disease as it is cheap, portable, safe and easy to access. The most commonly synthesized nanoparticle, that is, silver nanoparticle has various important beneficial properties due to their peculiar biocidal activity. Capparis decidua is one of the traditional remedies used plants for various medicinal treatments. Biological synthesis of metal NPs, a long established method that utilize plant extracts which has the ability for the control of disease, besides being safe and no phytotoxic effects. The method of green synthesizing silver nanoparticles using medicinal plants were found to be highly toxic against different pathogenic microorganisms. The synthesis involves reacting the silver metal stock solution with the stem extract of different stoichiometric ratio resulting in unique shapes and sizes of NPs. Yet another noteworthy feature of the present work is that the synthesized nanoparticles has significant antioxidant potential and antimicrobial efficacy. This enables the synthesis of silver nanoparticles by facile, non-hazardous, energy-frugal, and inexpensive methods; while gainfully utilizing the arid plant Capparis decidua (Forsk.).