Study’s purpose: to evaluate effect of educational program on quality of life among elderly patients with COPD. Methodology: A quasi-experimental design was conducted at chest diseases department in Sednawy Zagazig Hospitals. The Study sample was selected purposively which composed of 60 elderly. Data collected by a structured interview questionnaire, Saint George Respiratory Questionnaire, Modified Borg Dyspnea Scale, Pulmonary Function Test and COPD elderly patient’s practices. Major results: revealed post-program statistically significant improvements in QoL scores, elderly COPD knowledge and practices (P<0.001). The follow-up phase showed some declines, but still significantly higher compared with the pre- program levels (P<0.001). Clinical implications: there were improvements in knowledge, practice and quality of life compared with preprogram therefore, the education program should be implemented in the study setting on a long-term basis to test its sustainability, and in other settings to confirm its effectiveness and for further improvements.