The study included measurement of the biomarkers FGF-21 and pcsk9 in patients with myocardial infarction (MI) compared with healthy subjects and finding a correlation between biomarkers with the gender (25 females and 25 males) as well as type ST-elevation of myocardial infarction (MI). Blood samples were collected from patients with of the injured and admitted to the intensive care cardiac unit (CCU) in Al-Sadder Teaching Hospital in Al-Najaf province/ Iraq during the period from July to September, 2022. they are met (25) of healthy subjects. The result of this study revealed there was exhibit significant increase (p<0.05) in serum levels of FGF-21 in the patient (post-catheterization) MI group compared with in control group (476.8±50.01 &±41.1 pg/ml respectively) , but PCSK9 showed a significant decrease (p<0.05) in the patient (pre catheterization) MI group compared with control (9.805±2.11&17.66 ±2.56 pg/ml respectively). There were also changes on the type of gender and little in the level of MI-STE in the concentration level of both markers, which led to the conclusion of the research that the markers FGF-21 and PCSK9 are considered important indicators of the response of MI patients to catheterization or not.