Introduction: River Ganga plays a pivotal role in the lives of Indians either due to its water or due to its spiritual and religious significance but is suffering from the same ravaging issue i.e. Water Pollution. This severely affects the physical health of children which in turn affects their mental and psychological development. Aim: The aim was to study the effect of degrading water quality of river Ganga on mental and psychological wellbeing of children. Methodology: The present cross-sectional study was conducted in schools of Meerut and included healthy children in age group 4 to 8 years. The children were divided into two groups (near Ganga river and away from river bed) on the basis of school location. The psychological effect of children were compared by using pre-validated Pediatric Symptoms Checklist. The scales are further grouped into 3 subscales: Attention, Externalizing and Internalizing. Result: The study included 1426 children of 4 to 8 years. These include 715 children from villages near Ganga basin and 711 children from villages away from Ganga basin. The PCS score of 7.9% children residing in villages away Ganga was above cut-off score which was significantly greater than 36.51% children in villages near river Ganga was having PCS score above cut-off. The similar result was obtained for all the three subscales.